Synthesis of Self-immolative Disulfide Linear Polymers
Students: Sunirmal Pal, Andreas Sommerfeldt, Kaja Løvschall and Pere Monge Marcet
The self-immolative linear polymers would be interesting materials for industrial and biomedical applications as a self-immolative polymer is a polymer which can be triggered by an external signal to depolymerize. It is simply a system which can dissolve on demand.
The aim of the project is the synthesis of self-immolative linear polymers using diol protected (4R,5R)-1,2-dithiane-4,5-diol monomer as shown. The ketal group in the cyclic disulfide monomer increases the ring strain which will facilitate the formation of linear polymers. In addition, various substituents on the ketal may be introduced to control the polarity of the polymer. Normally, the self-immolative polymers are end capped by responsive units, which can be triggered by external stimuli to depolymerize the polymers. The end groups of the linear polymers can be end-capped by Ellman’s reagent as a triggering unit. The characterization of polymers and their depolymerisation could be done by techniques such as NMR and GPC.
Self-immolative linear polymers by anionic polymerization.