Open Science Festival May 31
Bringing Open Science to Life at the Neuro
Dr. Viviane Poupon, Montreal Neurological Institute and Hospital, McGill University
McGill University’s Montreal Neurological Institute and Hospital (aka the Neuro) recently launched a major scientific initiative, the Tanenbaum Open Science Institute (TOSI), with the ambitious goal of becoming the first-ever Open Science academic institution in the world. Through a bold transformation that will see the Neuro open its scientific data and biomaterials to institutions and scientists around the world, the Neuro is stepping to the forefront of a global movement that promises to revolutionize research and accelerate discovery and drug development for the benefit of patients, families and societies.
Open Science at the Neuro will be driven along five key axes: Open Access – Open Data – Open IP – Open Biobank – Open Commercialization. Dr. Poupon will present the philosophy, vision, mission and platforms, as well as the process leading to the establishment of TOSI.
Additive Manufacturing and Architected Materials
Material properties are governed by the chemical composition and spatial arrangement of constituent elements at multiple length-scales. This fundamentally limits material properties with respect to each other creating trade-offs when selecting materials for specific applications. For example, strength and density are inherently linked so that, in general, the more dense the material, the stronger it is in bulk form. We are combining advanced microstructural design, using flexure and screw theory as well as inverse methods, such as topology optimization, with advanced additive micro- and nanomanufacturing techniques to create new material systems with previously unachievable property combinations – mechanical metamaterials. The performance of these materials is fundamentally controlled by geometry at multiple length-scales rather than chemical composition alone. We have demonstrated designer properties of these mechanical metamaterials in polymers, metals, ceramics and combinations thereof. Properties include ultra-stiff lightweight materials, negative stiffness, and negative thermal expansion to name a few, as well as functional properties such electrical, optical, and chemical responses. We have primarily utilized our custom developed additive micro-manufacturing techniques to create these structures and materials. These include projection microstereolithography (PmSL), direct ink writing (DIW), and electrophoretic deposition (EPD). I will also touch on new advanced manufacturing concepts such as volumetric additive manufacturing, computed axial lithography, and diode-based additive manufacturing.
Dead Cheap Flow Reactors
Martin Bargum, Anders T. Lindhardt, Mogens Hinge
Synthesis of different chemicals are an important process impacting… err… everything! Some chemicals are very expensive to make either due to low yield or long reaction time. Think about a photocatalytic synthesis running in a batch or CSTR mode. In this case the light is only penetrating a few mm into the reaction media before it engages the chemicals and causes reaction. It is thus clear that only a minimum of the synthesis is illuminated and further the mixing of products back into the reactants will result in very long synthesis times or low yields. This challenge have been solved by flow reactors – but they are pricy (20,000 to 100,000+ DKK each) creating a limiting factor. Over the past 2 years we have developed a dead cheap production process for flow reactors made entirely in glass. Giving unlimited possibilities in reactor design, no limitations on solvents or the like, and a very good platform for experimenting with chemistries like heterogeneous synthesis, particle generation, packed beds, etc. The cool thing – if it fails then bin it and try again. This presentation will focus on the reactor design, production method, connectors, pumps, and other relevant items for the flow reactors we have developed.