Bone Promoting Coatings

Student: Carla Martin

Strontium (Sr) is known to promote the formation of bone. This has led to a number of coatings [1] and surface treatments containing Strontium, aimed at implants in contact with bone. A few studies has also reported an antibacterial effect of released Strontium [2]. A detailed mapping of the Sr-release is the basis for examining a possible combined antibacterial and bone-promoting effect of such coatings.

In this project we will characterize the actual release-rate and the resulting concentrations of Strontium, found at the bone/implant interface, subsequent to implantation. The technology that will be examined during this project will be based on Ti-O-Sr coatings prepared by physical vapour deposition (PVD). The research will be utilizing a setup resembling real in vivo applications.

Methods:

  • PVD for producing the coatings
  • XPS for chemical analysis of surface/release volume
  • EDX for further chemical characterization of the coating chemistry
  • ICP-AES for Sr release studies
  • Mammalian and potentially bacterial cell cultures
[1]: O. Z. Andersen et al, Biomaterials, 34 (2013) 5883-5890, [2]: D. S. Brauer et al., J. R. Soc. Interface, 20120647

 

Involved partnes: Aarhus University (Morten Foss), Elos Medtech

Data, progress, and status on the project is found here.

If you’re interested in hearing more about this project, SPOMAN or want to hear about the possibilities for starting a collaboration, please contact us at stinek@inano.au.dk.